NSAID or Non Steroidal Anti Inflammatory Drugs are the mainstay in treating pain but recent studies hints that it could also help to relieve depressive symptoms in combination with anti depressant.
The study was published in the online October 15 edition of JAMA Psychiatry. The results of the study link benefits of NSAID, in particular with selective COX inhibitors like Celecoxib in treating depression.
The evidence suggests that there could be a link between depression and inflammation. There have been studies in the past to ascertain if there is any anti depressant effects in NSAID. However there have not been any clear results from these studies.
Study authors, led by Ole Kohler, MD, of Aarhus University Hospital, Risskov, Denmark reviewed 14 trials which looked at the effects of anti inflammatory drug treatment in 6,262 subjects with depression related ailments.
Some of the studies were small and lasted for a short time. The studies also at times magnified the treatment effects.
However there is scope for more research especially in COX selective inhibitors like celecoxib.
The WHO has stated that depression is one of the five major causes which compromise the quality of life of a person.
Graduate student Ole Köhler, who is first author of the scientific article and a member of the research group from Aarhus University said, “The meta-analysis supports this correlation and also demonstrates that anti-inflammatory medication in combination with antidepressants can have an effect on the treatment of depression. When combined they give an important result which, in the long term, strengthens the possibility of being able to provide the individual patient with more personalized treatment options.”
Köhler further added, “The biggest problem with depression is that we do not know the causes that trigger the condition in the individual patient. Some studies suggest that the choice of antidepressant medication can be guided by a blood sample that measures whether there is an inflammatory condition in the body. Other studies show that the same blood samples could be used as a guideline on whether a depressive patient can be treated with anti-inflammatory drugs that works better when there is inflammation present simultaneously with the depression.”